Telomerase as an Androgen Receptor-Regulated Target in Selenium Chemoprevention of Prostate Cancer

Abstract

The present is to investigate telomerase as a potential target of AR signaling suppression by selenium. We found that combination of selenium and bicalutamide produced a robust downregulation of androgen receptor (AR) signaling and telomerase activity. Furthermore, apoptosis induction by the two agents is more significant compared to single treatment. Our findings thus indicate that selenium in combination with anti-androgen could represent a viable approach to improve the therapeutic outcome of androgen deprivation therapy. We also found that wild-type and mutant AR responses differentially to androgen under normoxia condition. However, in hypoxia condition, androgen up-regulates hTERT expression in both wild-type AR expressing cells and mutant AR expressing cells. Selenium is able to inhibit androgen-induced hTERT expression under hypoxia condition.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA535689

Entities

People

  • Shuang Liu

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chromosome Structures
  • Department Of Defense
  • Drug Therapy
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Regulations
  • Selenium
  • Therapy

Fields of Study

  • Biology

Readers

  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology