A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches

Abstract

A randomized, placebo-controlled clinical trial is being conducted to evaluate the effectiveness of propranolol, topiramate, and amitriptyline as treatments for chronic post-traumatic headaches secondary to combat-related mild head injury. The study is in the first of three years. 34 of 240 subjects have been enrolled. The study medications are well tolerated. Study subjects had a 60% decrease in headache frequency after 3 months of treatment. There is insufficient data at this time to draw conclusions about the efficacy of specific study medications. The study remains open to enrollment.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA535889

Entities

People

  • Jay Erickson

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Anticonvulsants
  • Brain Injuries
  • Clinical Trials
  • Department Of Defense
  • Diseases And Disorders
  • Frequency
  • Head Injuries
  • Headache Disorders
  • Health Services
  • Pain
  • Therapy

Fields of Study

  • Medicine

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Neurotrauma and Rehabilitation Medicine.