Feasibility of Nanoparticle-Guided Radiation Therapy (NGRT) Using a Conventional CT Scanner

Abstract

Recent studies have demonstrated preferential accumulation of nanoparticles within tumor. By combining high Z nanoparticles (such as gold) with x-rays from a conventional CT scanner, a significant radiation dose enhancement is possible. In this study, the dose enhancement was quantified based on nanoparticle accumulation within a vessel inside of a phantom. Monte Carlo calculations based on a nanoparticle uptake of 10 mg/g irradiated with 140 kVp x-rays from a CT scanner resulted in a radiation dose enhancement of 2.45. That is, a delivered radiation dose of 10 Gy would be equivalent to delivering 24.5 Gy. The results of this study suggest that this approach holds the potential to deliver a significant dose to the tumor, while limiting the dose to the surrounding normal tissues.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA536518

Entities

People

  • John C. Roeske

Organizations

  • Loyola University New Orleans

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption Coefficients
  • Algorithms
  • Biomedical Research
  • Detectors
  • Geometry
  • Ionization Chambers
  • Ionizing Radiation
  • Materials
  • Measurement
  • Metallic Nanoparticles
  • Nanoparticles
  • Neoplasms
  • Radiation
  • Radiography
  • Simulations
  • Spectra
  • X Rays

Fields of Study

  • Medicine
  • Physics

Readers

  • Medical Imaging.
  • Nanocomposite Materials Science
  • Nuclear and Radiation Engineering.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech