Diagnosis of 2009 Pandemic Influenza A (pH1N1) and Seasonal Influenza Using Rapid Influenza Antigen Tests, San Antonio, Texas, April-June 2009
Abstract
Clinicians frequently use influenza rapid antigen tests for diagnostic testing. We tested nasal wash samples from 1 April to 7 June 2009 from 1538 patients using the QuickVue Influenza A1B (Quidel) rapid influenza antigen test and compared the results with real-time reverse transcription polymerase chain reaction (rRTPCR) assay (gold standard). The prevalence of 2009 pandemic influenza A (pH1N1) was 1.98%, seasonal influenza type A .87%, and seasonal influenza type B 2.07%. The sensitivity and specificity of the rapid test for pH1N1 was 20% (95% CI, 8-39) and 99% (95% CI, 98-99), for seasonal influenza type A 15% (95% CI, 2-45) and 99% (95% CI, 98-99), and for influenza type B was 31% (95% CI, 9-61) and 99% (95% CI, 98-99.7). Rapid influenza antigen tests were of limited use at a time when the prevalence of pH1N1 and seasonal influenza in the United States was low. Clinicians should instead rely on clinical impression and laboratory diagnosis by rRT-PCR.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- ADA536870
Entities
People
- Alicia C. Guerrero
- Genny M. Maupin
- Jenny L. Butler
- Linda C. Canas
- Oliver W. Morgan
- Pauline M. Lucas
- Sonja J. Olsen
- Thomas F. Gibbons
- Victor H. Macintosh
- Vincent P. Fonseca
Organizations
- United States Air Force School of Aerospace Medicine