Neuroinflammatory Pathobiology in Gulf War Illness: Characterization With an Animal Model

Abstract

Gulf War Illness (GWI) is a multi-symptom disorder with features characteristic of "sickness" behavior, a normal manifestation of an inflammatory response due to infection or injury, findings suggestive of a heightened or chronic neuroimmune/neuroinflammatory disorder. Our overarching hypothesis is that exposure to GWI-relevant compounds lead to enhanced and/or prolonged expression of neuroinflammatory mediators in the brain. Our overall objective is to establish a neuroinflammatory model of GWI-related exposures, to define the contribution of high physiological stress, and to assess the potential for current pharmacotherapy to ameliorate these effects. However, after lengthy discussion on how to set up a fiscal relationship between the performing organization (UIC) and collaborators at the CDC, USAMRMC contracting officials required that a CRADA be established. Due to the extended period necessary to put this agreement into place, work on the project has just begun.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2010
Accession Number
ADA537179

Entities

People

  • Stephen M. Lasley

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Agreements
  • Biomedical Research
  • Business Administration
  • Contract Administration
  • Contracts
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Financial Management
  • Grants
  • Infection
  • Information Operations
  • Management Personnel
  • Medical Personnel
  • Persian Gulf Syndrome
  • Stress (Physiology)

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.