Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multi-Ethnic Cohort Experience
Abstract
Most prostate cancer(PCa) research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicity/race. There are strong racial disparities in mortality with African-Americans twice as likely to die from PCa compared to Caucasians; very little data are available in Hispanics. Our goal is to identify markers of PCa progression in a multiethnic cohort (773 Caucasians, 361 African-Americans and 246 Mexican-Americans). Medical records for all participants have been abstracted, and we are updating vital status using the National Death Index. We are multiplexing the genotyping assays to optimize the utilization of our archived specimens, and all DNA extractions have been completed. Our research may help explain ethnic/racial disparities in PCa progression and provide direction towards eliminating these disparities and may guide future studies to develop ethnic/racial specific interventions to improve outcome in the most common cancer in American men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2010
- Accession Number
- ADA537888
Entities
People
- Sara S. Strom
Organizations
- The University of Texas MD Anderson Cancer Center