Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

Abstract

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities. In this paper we review and discuss intriguing recent developments in the use of histone deacetylase inhibitors (HDACIs) to combat some critical conditions in an animal model of hemorrhagic and septic shock. HDACIs have neuroprotective, cardioprotective, renal-protective, and anti-inflammatory properties; survival improvements have been significantly shown in these models. We discuss the targets and mechanisms underlying these effects of HDACIs and comment on the potential new clinical applications for these agents in the future. This paper highlights the emerging roles of HDACIs as acetylation modulators in models of hemorrhagic and septic shock and explains some contradictions encountered in previous studies.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA537950

Entities

People

  • Hasan B Alam
  • Yongqing Li

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Enzyme Inhibitors
  • Gene Expression
  • Health Services
  • Hemorrhagic Shock
  • Neurodegeneration
  • Peptide Growth Factors
  • Proteins
  • Sepsis

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics
  • Systems Analysis and Design