Mutagencity Testing of WR238605 Succinate

Abstract

WR238605 Succinate was tested for point mutations and chromosomal aberrations in three in vitro mutagenicity tests. WR238605 Succinate was shown to be negative in the chromosomal aberrations test but was equivocal in the mouse lymphoma assay, which tested for point mutations. Accordingly, a second in vitro test for point mutations, the CHO/HGPRT assay, was performed. WR238605 Succinate was negative in this follow-up point mutation assay, and a subsequent confirmatory in vivo mutagenicity test is not warranted. Accordingly, the test article does not appear to represent a genotoxic hazard.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 03, 1996
Accession Number
ADA538026

Entities

People

  • Barry S. Levine
  • Patrick T. Curry
  • Richard H. San

Organizations

  • University of Illinois at Chicago

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Anti-Bacterial Agents
  • Cell Line
  • Cell Physiological Processes
  • Chemistry
  • Chromosome Aberrations
  • Chromosomes
  • Culture Techniques
  • Data Analysis
  • Detection
  • Genetics
  • Laboratory Procedures
  • Liquid Chromatography
  • Mutagenicity Tests
  • Mutations
  • Pharmacology
  • Toxicity

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Toxicology/Environmental Toxicology