Targeting Neuropilin-1 in Prostate Cancer Bone Metastasis
Abstract
Overexpression of neuropilin-1 (NRP1) has been implicated with progression of prostate cancer (PCa) and other solid tumors. However, it remains elusive for the role of NRP1 in those cancer cells lacking the "classics" vascular endothelial growth factor receptors (VEGFRs). Our studies have demonstrated myeloid cell leukemia (Mcl-1) as a novel downstream target of NRP1 signaling in metastatic prostate cancer cells. During the third year of the supporting period, we correlated Mcl-1 overexpression with PCa bone metastasis, and elucidated a signaling mechanism by which NRP1 regulates Mcl-1 expression. These findings provide an excellent rationale to develop NRP-1-targeted therapy treating bone metastatic PCa.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2010
- Accession Number
- ADA538180
Entities
People
- Daqing Wu
Organizations
- Emory University