Differential Expression of Zinc Transporters in Prostate Epithelia of Racial Groups
Abstract
In the award (W81XWH-08-1-0626), the stated goals are to study the zinc transporters that may be disparately expressed in the prostate tissues of African American (AA) males as compared to European American (EA) males. This may lead to the identification of the potential molecular targets for preventive or therapeutic measures, nutritional, environmental or life style factors for their potential relationship to the incidence or progression of prostate cancer in various racial groups. The following tasks are to be carried out in a synergistic fashion between the laboratories of Dr. Bagasra (Claflin University) and Dr. Balla (University of Illinois, Chicago). The prostate tissues, pre-made tissue microarrays (TMAs) and primary cell lines will be obtained from the NCI -initiated "Cooperative Prostate Cancer Tissue Resource (CPCTR)" by Dr. Balla, one of the P.I.s of the present proposal and of the CPCTR. The main tissue microarray to be used is composed of agematched and the Gleason score-matched prostate tissues with representative tissues from 150 African Americans males and 150 European American males. Other TMAs will be used to address questions of whether hZIP gene and protein expression is associated with poor outcome and/or Gleason grade. Significant progress has been made in each of the three TASKS proposed in the essence of one peer-reviewed publication as well as numerous oral and poster presentations. We currently have three additional publications in preparation for peer reviewed journals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA538184
Entities
People
- Omar Bagasra
Organizations
- South Carolina State University