Targeted Virus Nanoparticles for Localized Chemotherapy of Breast Cancer
Abstract
We aim to develop a new approach to treat breast cancer by targeting the commonalities that exist in all breast tissue (normal and malignant) to enhance delivery of chemotherapy to breast cancer and minimize delivery to non-breast tissue. We propose to create novel chemotherapeutic-carrying virus nanoparticles (VNPs) for localized drug delivery to breast tissue. We have successfully completed tasks 1-3 of our SOW. Specifically, we have attached paclitaxel on the AAV capsid at various ratios to create AAV-taxol conjugates, characterized the properties of the conjugates using a variety of assays to verify attachment, and created large diverse AAV capsid gene and particle libraries that are now ready to be used to select for virus variants with improved selectivity for breast cells. Highly targeted, multivalent drug delivery systems that can deliver chemotherapeutic drugs selectively to breast tissue cells have the potential to substantially improve the efficacy of chemotherapy while considerably reducing the magnitude of debilitating side effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2010
- Accession Number
- ADA538233
Entities
People
- Junghae Suh
Organizations
- Rice University