Reducing Prostate Cancer Disparities Through Behavioral and Biologic Epidemiologic Approaches
Abstract
This study seeks to define the optimal dose of vitamin D supplementation in Blacks needed for future intervention efforts in the prevention of prostate cancer. Study subjects were randomized to placebo, 1000IU, 2000IU, or 4000IU of vitamin D3 per day to determine the minimum dose of vitamin D needed to achieve an optimal level. After 3 months of supplementation, plasma levels of 25(OH)D and PSA are determined and compared to baseline levels. We also assessed of 25(OH)D and PSA 6 months. The goal was to enroll 320 participants, including 100 men, into the study. A 3-phase eligibility and consent process was use. Only people who were AA, English-speaking, and 30-80 years old were approached to participate in the study; Basic non-clinical eligibility criteria were assessed;3.Primary care were contacted to assess clinical eligibility. To encourage retention, a case-manager approach was implemented which included biweekly calls and monthly pill bottle exchange visits. We consented 572 individuals and exceeded our recruitment goals with 329 participants enrolled in the study, including 107 men. Retention for the 3- and 6-month assessment was 90.54% and 89.13%, respectively. The supplementation and follow-up periods for this study has recently completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA538369
Entities
People
- Bettina F. Drake
Organizations
- Washington University in St. Louis