Understanding the Mechanisms Of Platelet Alloimmunization And Its Prevention
Abstract
We have used a dog platelet transfusion model to evaluate methods of preventing alloimmune platelet refractoriness. Our initial hypothesis was that filtration leukoreduction, when convinced with gamma-irradiation, would prevent alloimmunization. However, this approach was successful in only 2/11 recipient dogs (18%). Over the past year, we have switched our approach to determine if a pathogen reduction process involving adding riboflavin to the platelets followed by UV-irradiation (mirasol technology), when combined with filtration leukoreduction, would be successful. We have been able to prevent alloimmune platelet refractoriness using this approach in 13/14 (93%) of recipient dogs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA538562
Entities
People
- Karen A. Nelson
- Lakshmi Gaur
- Sherrill J. Slichter
- Yvette E. Latchman