Molecular Targets for Prevention of Prostate Cancer

Abstract

The objectives of this proposal are to determine whether protein kinase C epsilon (PKC-epsilon) is linked to the initiation and progression of Prostate cancer (PCa) and should be explored as a molecular target for the prevention of human PCa. PKC-epsilon, a calcium-insensitive PKC, is among the PKC isoforms expressed in both mouse and human prostate tissue. We plan to test the hypothesis that PKC-epsilon is linked to the onset, progression and metastasis PCa. Two specific aims are proposed to test this hypotheses. Specific Aim #1: To obtain the first molecular genetic evidence that PKC-epsilon is linked to the development of PCa. To accomplish this specific aim, we will employ TRAMP mice, the well-established mouse model of PCa.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2009
Accession Number
ADA538690

Entities

People

  • Ajit K. Verma

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Adenocarcinoma
  • Antibodies
  • Biomedical Research
  • Blood
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Immunoproteins
  • Lymph Nodes
  • Lymphatic System
  • Materials
  • Neoplasms
  • Oncology
  • Programmed Cell Death
  • Prostate Cancer
  • Proteins

Fields of Study

  • Biology

Readers

  • Agent-Based Social Robotics and Mobile-Assisted Learning in Virtual Environments.
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology