Bacillus Anthracis Spore Interactions with Mammalian Cells: Relationship Between Germination State and the Outcome of in Vitro Infections

Abstract

During inhalational anthrax, internalization of Bacillus anthracis spores by host cells within the lung is believed to be a key step for initiating the transition from the localized to disseminated stages of infection. Despite compelling in vivo evidence that spores remain dormant within the bronchioalveolar spaces of the lungs, and germinate only after uptake into host cells, most in vitro studies of infection have been conducted under conditions that promote rapid germination of spores within the culture medium.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 2011
Accession Number
ADA539009

Entities

People

  • Angela M. Prouty
  • Batcha Tamilselvam
  • Bojana Stojkovic
  • Ian M. Gut
  • Stephanie N. Czeschin
  • Steven R. Blanke
  • Wilfred A. Van Der Donk

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alanine
  • Amino Acids
  • Anti-Bacterial Agents
  • Azo Compounds
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Epithelial Cells
  • Experimental Design
  • Germination
  • Infection
  • Macrophages
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Military/Explosive Ordnance Disposal (EOD) Technology

Technology Areas

  • Space