Gene Expression Profiling of Rat Hippocampus Following Exposure to the Acetylcholinesterase Inhibitor Soman
Abstract
Soman (O-pinacolyl methylphosphonofluoridate) is a potent neurotoxic ant. Acute exposure to soman causes acetylcholinesterase inhibition, resulting in excessive levels of acetylcholine. Excessive acetylcholine levels cause convulsions, seizures, and respiratory distress. The initial cholinergic crisis can be overcome by rapid anticholinergic therapeutic intervention, resulting in increased survival. However, conventional treatments do not protect the brain from seizure-related damage, and thus, neurodegeneration of somansensitive brain areas is a potential postexposure outcoVle. We performed gene expression profiling of the rat hippocampus following soman exposure to gain greater insight into the molecular pathogenesis of soman-induced neurodegeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- ADA539450
Entities
People
- Christina P. Tompkins
- Christopher S. Phillips
- Denise M. Kniffin
- James F. Dillman Iii
- Robert K. Kan
- Tracey A. Hamilton
Organizations
- United States Army Medical Research Institute of Chemical Defense