Critical Role of CD8 T Cells in Mediating Sex-Based Differences in a Murine Model of Lupus

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a well-characterized but poorly understood female predominance in its prevalence. The DBA into B6D2F1 (DBA->F1) model of chronic graft versus host disease (cGVHD) exhibits a lupus-like glomerulnephritis (GN) that results from immune complex deposition in the kidneys. Following the transfer of unfractioned DBA splenocytes into an unirradiated BDF1 host, parental strain DBA CD4 T cells recognize the B6 parental strain MHC II on all host B cells, which subsequently become activated and produce large amounts of anti-DNA and anti-nuclear autoantibodies. The subsequent renal disease has a strong female predilection in disease severity, comparable to SLE, making it a useful model for the investigation of sex-based differences in lupus.

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Document Details

Document Type
Technical Report
Publication Date
Aug 21, 2009
Accession Number
ADA539491

Entities

People

  • Anthony D Foster

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Autoimmune Diseases
  • Autoimmunity
  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Disease Attributes
  • Genetics
  • Kidney Diseases
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel

Fields of Study

  • Biology
  • Medicine

Readers

  • Gender and Food Studies
  • Immunology
  • Neurological Diseases/Conditions/Disorders