Impaired Auditory and Contextual Fear Conditioning in Soman-Exposed Rats
Abstract
Exposure to soman (GD) can result in prolonged seizures and subsequent neuropathology in a variety of brain regions including the amygdala and hippocampus. Both regions are believed to play important roles in the development and expression of fear conditioning. The purpose of this experiment was to test these conditioning tasks as a possible behavioral correlate of the observed neuropathology. Male rats were exposed to GD (1.0 or 1.2 LD50) or saline followed with injections of atropine sulfate, the oxime HI-6 and diazepam. Fear conditioning was conducted on post-exposure day (PED) 8 followed by measuring freezing to contextual and auditory conditioned stimuli on PED 9 and 10 respectively. Contextual and auditory fear conditioning was severely impaired in both the 1.0 LD(50) and 1.2 LD(50) GD groups. Both GD groups spent less time freezing than controls when returned to the context in which conditioning occurred. The 1.0 LD(50) and 1.2 LD(50) groups had very low levels of freezing following presentation of the auditory conditioned stimulus. Neuronal fiber degeneration was present in the piriform cortex, thalamus, and amygdala in GD-exposed animals regardless of dose. The present study suggests that contextual and auditory fear conditioning is impaired in GD-exposed rats possibly due to neuropathology observed in the hippocampus, amygdala and thalamus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2011
- Accession Number
- ADA539935
Entities
People
- Julia E. Schwartz
- Lucille A. Lumley
- Mark C. Moffett
- Mark K. Schultz
- Michael F. Stone
Organizations
- United States Army Medical Research Institute of Chemical Defense