Achilles Heel of ETS Fusions

Abstract

In prostate cancer TRMPRSS2-ETS fusions are common, but not readily druggable. Our study aims to discover novel therapeutic targets displaying synthetic lethal (or Achilles' heel) interaction with ETS fusions, using a highly multiplexed RNA interference-based approach. Towards this goal, key accomplishments during the first year include the creation and validation of ETS knockdown and inducible prostate cell lines; the piloting and optimization of pooled shRNA barcode screens; and the completion of the first whole-genome shRNA screens. Future efforts will focus on the completion of screens, analysis of data, and validation of positive hits as genes that are selectively targetable in the context of ETS fusions.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2010
Accession Number
ADA540242

Entities

People

  • Jonathan R. Pollack

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Genomic Instability
  • Infection
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Targeting
  • Targets
  • Transcription Factors
  • Validation

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