Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alterations in CNS Development

Abstract

The interactions of biomarkers of oxidative stress with various dye molecules and antibodies have been investigated to explore possible venues for designing sensors for these biomarkers. This was followed by the development of several sensor types and testing their performance. Printed circuits were developed for single microsensors and for sensor arrays. The oxidative stress biomarkers, including glutathione (GSH), glutathione disulphide, cysteine, and homocysteine, were also studied in processes of ligand exchange in core-shell gold nanoparticles for application in novel assays for GSH, cysteine and homocysteine, as well as for the enhancement of sensor sensitivity. The monoclonal anti-GSH antibody piezoimmunosensors and molecular beacons for the detection of GSH have been designed and tested. The neural network analysis of sensor signals from the same type of sensors has been developed and will be applied to the analysis sensor arrays during the third year of the Project.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA540344

Entities

People

  • Maria Hepel

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Amino Acids
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Health Services
  • Indicator Dyes
  • Materials Processing
  • Materials Science
  • Materials Testing
  • Metallic Nanoparticles
  • Molecular Dynamics
  • Nanotechnology
  • Optical Properties
  • Optics
  • Surface Plasmon Resonance

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).
  • Sensor Fusion and Tracking Systems.

Technology Areas

  • AI & ML
  • Biotechnology