Evaluation of Toosendanin as a Botulinum Neurotoxin Antagonist

Abstract

Toosendanin (TSN), a tetranortriterpenoid compound from the plant Melia toosendan, has been reported to protect rats and non-human primates from the lethal actions of botulinum neurotoxin A (BoNT/A). TSN was tested in isolated mouse phrenic nerve-hemidiaphragm preparations against BoNT serotypes A, B and E. When added prior to toxin, TSN was found to delay the onset of muscle paralysis with all 3 BoNT serotypes. TSN had little or no effect on BoNT-induced muscle paralysis when applied 30 min after BoNT. It is suggested that the antagonist activity of TSN may result from inhibition of BoNT translocation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2008
Accession Number
ADA540577

Entities

People

  • James D. Nicholson
  • Michael Adler

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Albumins
  • Animals
  • Biomedical Research
  • Botulism
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Electronic Mail
  • Laboratory Animals
  • Neurotoxins
  • Peripheral Nervous System
  • Pharmacology
  • Phrenic Nerves
  • Small Molecules
  • Test And Evaluation
  • Toxins

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Neuroscience