tRNAs as Biomarkers and Regulators for Breast Cancer

Abstract

tRNA reads mRNA codons in translation and is essential for protein synthesis. Like mRNA, tRNAs are also under stringent cellular control. Our proposal aims to determine the feasibility of using tRNA expression as biomarkers for breast cancer type and progression, and how tRNAs are used to regulate gene expression in breast cancer cells. We found that the expression of both nuclear and mitochondrial-encoded tRNAs can be useful as possible biomarkers for breast cancer. Furthermore, tRNA expression also correlates in some way to certain groups of breast cancer related genes. These results demonstrate that studies of tRNA and breast cancer biology will be useful in understanding breast cancer type and progression and may lead to new drug targets for breast cancer treatment.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2010
Accession Number
ADA540678

Entities

People

  • Marsha Rosner
  • Tao Pan

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biodiesels
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Gene Expression
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Transcription Factors
  • Trna

Fields of Study

  • Biology

Readers

  • Computer Engineering
  • Molecular Genetics
  • Oncology (Cancer Research).