The Role of MicroRNAs in Human Prostate Cancer

Abstract

We have made significant progress in our analysis of genomic alterations, including those of microRNAs, in prostate cancer over the last two years. We have completed the genomic characterization of almost 250 primary and metastatic prostate cancer samples, which, in addition to microRNA expression profiles, included DNA copynumber profiling, mRNA expression, and exon-sequencing of selected genes. Using these data, we have identified microRNAs that are regulated by copy-number changes and have identified biological processes that appear to be regulated by changes in microRNA expression.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2010
Accession Number
ADA540731

Entities

People

  • Anders Jacobsen
  • Chris Sander
  • Nikolaus Schultz
  • William L. Gerald

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biological Processes
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Data Sets
  • Department Of Defense
  • Diseases And Disorders
  • Neoplasms
  • New York
  • Prostate
  • Prostate Cancer
  • Regulations
  • Targets

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.