Breast Cancer-Targeted Nuclear Drug Delivery Overcoming Drug Resistance for Breast Cancer Chemotherapy
Abstract
Cell membrane-associated and intracellular drug resistance mechanisms are the major cause of breast cancer treatment failure. The aim of this proposal is to develop nuclear localizing nanoparticles to deliver DNA-toxins breast cancer cell nuclei to effectively overcoming the drug resistance. We finished the task 1? To synthesize and optimize folic-acid? or LHRH-functionalized charge reversal nanoparticles. The cationic polymer PEI and its block copolymer with degradable PCL were synthesized. The cationic PEI block amines were converted to acid labile amides to obtain the PCL-PEI/amide block copolymer. This polymer was used to fabricate the nanoparticles. The ideal nanoparticles with optimal sizes and acid-triggered negative-to-positive charge reversal properties were fabricated and characterized carefully. These nanoparticles will be characterized in vitro and in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA540925
Entities
People
- Maciej Radosz
- William J. Murdoch
- Youqing Shen
Organizations
- University of Wyoming