Identification of Novel Breast Cancer Metastasis-Suppressor Genes

Abstract

The recurrence of breast cancer (BrCa) at distal, metastatic sites, such as in the lung or in the bones, presents the greatest impact on patient mortality. We propose to identify genes that promote or suppress metastatic growth of BrCa, and in doing so, identify potential genetic signatures useful in either predicting or diagnosing BrCa spread or as potential new targets for anti-BrCa drugs. The metastasis-suppressor (MetSup) or -inducer (MetInd) genes were identified by introducing two different genomic screening virus pools, GIPZ or VBIM, into tagged human BrCa cells (T47D/luciferase) with poor metastatic growth potential, and then selecting for cells that gain high metastatic potential in a cell culture assay. Preliminary analysis has begun on analyzing these potential inducers (MetInd) or suppressors (MetSup) of BrCa metastasis by analyzing human BrCa tissue arrays.

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Document Details

Document Type
Technical Report
Publication Date
Aug 17, 2010
Accession Number
ADA540929

Entities

People

  • Irwin H Gelman

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • Bar Codes
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Gene Expression
  • Genetic Structures
  • Human Genome
  • Identification
  • Lymph Nodes
  • Metastasis
  • Neoplasms
  • Proteins
  • Suppressors

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Systems Analysis and Design

Technology Areas

  • Biotechnology