The Effects of rhBMP-2 Used for Spinal Fusion on Spinal Cord Pathology After Traumatic Injury

Abstract

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a promising new therapeutic for spinal fusion procedures. Currently, rhBMP-2 is used "off-label" for spinal fusion in cases where there is concomitant spinal cord injury (SCI), yet little is known about the direct effects of rhBMP-2 on the recovery from a SCI. We therefore performed a series of studies in rats to determine whether rhBMP-2, used for spinal fusion, could penetrate the injured spinal cord. Additionally, we sought to determine whether the use of rhBMP-2 led to morphologic changes within the injured spinal cord that may alter functional recovery from SCI.

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Document Details

Document Type
Technical Report
Publication Date
Jul 29, 2009
Accession Number
ADA540966

Entities

People

  • Anton E. Dmitriev

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Chemistry
  • Intercellular Junctions
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Spinal Cord
  • Spinal Injuries
  • Spine

Fields of Study

  • Biology

Readers

  • Neurotrauma and Rehabilitation Medicine.