Role of Mesenchymal Stem Cells In Tumorigenesis
Abstract
The project on the bone marrow transplantation, reconstitution and formation of adipose tissue derived stem cells (ASC) derived clusters in the lung has been accomplished in time as originally planned in the Statement of Work of my grant proposal. We detected GFP+ cells in the lung prior to the arrival of tumor cells and the co-localization of both GFP+ and tumor cells was detected at later time points. These data indicate that ASCs formed a niche in preparation for the arrival of tumor cells. These encouraging data confirmed our hypothesis that breast tumor cells produce growth factors/cytokines that direct the mobilization and homing of a specific subpopulation ASCs to pre-metastatic sites to form a niche before the arrival of tumor cells. These data are important because it forms the foundation for the continuation of the remaining proposed projects to determine the cellular and molecular mechanisms by which migratory stem cells, through interaction with the microenvironment, form permissive pre-metastatic niches and to define specific growth factors/cytokines responsible for the mobilization and homing of ASCs to pre-metastatic sites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2009
- Accession Number
- ADA541309
Entities
People
- Yao-hua Song
Organizations
- The University of Texas MD Anderson Cancer Center