Neural Stem Cell Delivery of Therapeutic Antibodies to Treat Breast Cancer Brain Metastases
Abstract
Our goal is to develop a therapeutic approach for clinical inhibition of breast cancer brain metastasis. Our work has identified a new molecular target for treatment of metastatic brain disease in breast cancer patients and provided antibody tools that successfully interrupt breast cancer metastasis in a mouse model. Systemic application of the antibodies does not sufficiently reach brain lesions to interfere with their development and progression. Therefore, we are developing delivery strategies to bring therapeutic antibodies to brain metastatic lesions and inhibit their proliferation. We have established and validated unique new breast cancer brain metastasis cell models and adapted mouse models to emulate all steps of human breast cancer brain metastasis development and invasive progression. These models are essential new tools for the evaluation of successful new therapies against widespread metastatic brain disease as seen in breast cancer patients. By investigating initial as well as late stages of brain metastasis development in the animal model, we have identified host cell responses that can be potentially used as therapeutic targets and for delivery of therapeutic molecules to disseminated breast cancer brain lesions. With these advances, we have made tangible progress toward new treatment options for breast cancer patients with cerebral metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2009
- Accession Number
- ADA541313
Entities
People
- Brunhilde Felding-habermann
Organizations
- Scripps Research