PT-Cell Gene Therapy to Eradicate Disseminated Breast Cancers

Abstract

This represents work performed under year 1 of our Breast Cancer IMPACT award. The goals of the award are clinical trials with designer T cells in breast cancer, but also preclinical development work to bring new configurations to the clinic. Following completion of harmonization of the clinical protocol with the HSRRB, patient enrollments are expected to begin in August, 2010. Other laboratory work has been performed to begin to assess the use of additional domains from T cell signaling molecules to improve the characteristics of the designer T cells for patient use. Under US Army support, a new technique has been developed to improve the gene expression for additional signals in the designer T cells for which a patent has been file.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA541984

Entities

People

  • Richard P. Junghans

Organizations

  • Roger Williams Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Buildings And Structures
  • Cell Physiological Processes
  • Cells
  • Clinical Trials
  • Demographic Cohorts
  • Department Of Defense
  • Diseases And Disorders
  • Gene Expression
  • Gene Therapy
  • Lymphocytes
  • Molecules
  • Neoplasms
  • Secretion
  • Virotherapy

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Oncology (Cancer Research).
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech