The Effect of Hypotensive Resuscitation and Fluid Type on Mortality, Bleeding, Coagulation and Dysfunctional Inflammation in a Swine Grade V Liver Injury Model
Abstract
To determine the efficacy of an initial bolus of resuscitative fluids currently utilized in military and civilian settings on the physiologic response to uncontrolled hemorrhage. Scope: 50 swine underwent A grade V liver injury was performed, followed by 30 minutes (30') of uncontrolled hemorrhagic shock. After 30', liver packing was completed and randomized blinded fluid resuscitation was initiated over a 12' period with two liters of normal saline (NS), two liters of Lactated Ringer's (LR), 250 ml of 7.5% saline with 3% Dextran (HTS), 500 ml of Hextend (HEX), or no fluid (NF). Animals were monitored for 2 hours post injury. Physiologic parameters, coagulation assays and inflammatory mediators were compared. Major Findings: The NF group had less post-treatment blood loss compared to the fluid groups. MAP and StO2 for HEX, HTS, and LR at 1 HR and 2 HR were comparable and superior to NF. NS was not statistically different from NF for MAP and StO2 but did result in lower pH and decreased base excess.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2011
- Accession Number
- ADA542032
Entities
People
- Jerome Differding
- Martin A. Schreiber
- Nicholas Kunio
- Philbert G. Hamilton
- Ross Anderson
Organizations
- Oregon Health & Science University