Neuroprotective Strategies After Repetitive Mild Traumatic Brain Injury (mTBI)
Abstract
To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (Vitamin B3). Scope: In rat model of a repetitive mild cortical controlled injury, we will investigate the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of nicotinamide right after the first mTBI impact will be evaluated using the MRI and histological biomarkers. Major Findings: Two sessions of mTBI with 3d apart resulted in significant increase in lesion volumes derived from T2WI and hemorrhagic lesion derived from SWI. Ex vivo histology examination confirms the in vivo neuroimaging findings. HBO pretreatment significantly reduced the lesion volume and hemorrhagic lesion in rmTBI with either 3d or 7d apart. Progress Report: There is cumulative neuropathology following repetitive mTBI. The initial mTBI event renders the brain vulnerable to the subsequent mTBI up to 3 days. HBO pretreatment prior to the initial mTBI appears to prevent the detrimental consequences of either single mTBI or repetitive mTBI events.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2010
- Accession Number
- ADA542080
Entities
People
- Andre Obenaus
Organizations
- Loma Linda University