Use of PET Imaging for Early Detection of Ovarian Carcinoma
Abstract
We proposed to investigate the role of our newly designed PET imaging probe (FMDHT) in the early detection of ovarian cancer using PET. Our probe is specifically designed to target androgen receptors. Since ovarian cancers also express these receptors, we anticipated that FMDHT may be able to detect these receptors at an early stage when the tumor isles aggressive and possibly managed easier. To accomplish that, we proposed and performed assessment of FMDHT accumulation in ovarian cancer xenografts (OVCAR) using female mice. Although, FMDHT accumulated in these tumors, the receptor concentration was low in these tumors, thus eluding the copious accumulation of this probe. In addition, we assessed the accumulation of FMDHT in female monkeys, especially in the ovaries. Our initial hypothesis was that since the androgen receptor concentration is low in normal ovaries, FMDHT would accumulate sparingly in normal ovaries of non-human primates. We then hypothesize that the androgen receptor concentration would increase (much higher) during the malignancy, we would observe and increased probe signal in presence of ovarian cancer. As expected, PFDHT accumulation in the ovaries was low and could not differentiate normal ovaries from other normal tissues. This was an important and encouraging property of this imaging probe. In near future, we would like to extend this observation to cancer model in large animal species to assess the ability of FMDHT in detecting androgen receptor positive ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA542182
Entities
People
- Pradeep K. Garg
Organizations
- Wake Forest University