Noninvasive Subharmonic Pressure Estimation for Monitoring Breast Cancer Response to Neoadjuvant Therapy

Abstract

Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer (LABC). Monitoring tumor response is advantageous for patients. This project aims at establishing noninvasive monitoring of neoadjuvant chemotherapy in the breast using subharmonic aided pressure estimation (SHAPE) to estimate the interstitial fluid pressure (IFP) in LABC. To date, in vitro experiments with the ultrasound contrast agent Definity have showed an inverse linear relationship between the change in subharmonic amplitude and hydrostatic pressure (r2 = 0.79-0.99, p < 0.01) over the pressure range associated with breast tumors (0 - 50 mmHg). Moreover, software for analyzing RF data from a Sonix RP scanner to produce SHAPE pressure estimates has been successfully optimized and submitted for publication. In vivo proof of concept for SHAPE as a noninvasive monitor of IFP (r2 > 0.81, p < 0.01) has been provided based on a swine model. However, difficulty with standing waves in the in vitro setup has delayed the project by approximately 9 - 12 months.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2010
Accession Number
ADA542189

Entities

People

  • Fleming Forsberg

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Arrays
  • Breast Cancer
  • Department Of Defense
  • Elastic Properties
  • Encapsulation
  • Fluid Dynamics
  • Frequency
  • Hydrostatic Pressure
  • Linear Arrays
  • Measurement
  • Neoplasms
  • North America
  • Pressure Measurement
  • Standing Waves
  • Static Pressure
  • United States
  • Water Tanks

Readers

  • Cardiovascular Physiology
  • Medical Imaging.