Inhibition of Ras Signaling in Neurofibromitosis
Abstract
The purpose of the proposed research is to screen for small molecules that interfere with the signaling of Ras in Neurofibromitosis. During this research period, an 'open conformation' of Ras that is non-signaling has been generated. The current hypothesis is that this new conformation is adopted by Ras in the GTP-bound form before it adopts its active effector-binding conformation and therefore is a target for inhibition by small molecules that would attenuate the signaling of hyper-activated Ras in Neurofibromitosis and in other human cancers. Small molecules are being screened for their ability to inhibit or decrease the in vitro binding of Ras to downstream effectors including Raf.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA542267
Entities
People
- Nicolas Nassar
Organizations
- State University of New York