Inflammatory Markers and Breast Cancer Risk
Abstract
Mammographic breast density is one of the strongest known risk factors for breast cancer, and a marker of cancer risk for both breasts. Information on the etiology of breast density is currently limited. To gain further insight into the role of inflammatory cytokines in the etiology of breast density, this study investigates associations between circulating cytokine levels, genetic variation in cytokine genes, and breast density using data and samples from the Mammograms and Masses Study (MAMS). This report provides information on the progress made during the fourth year (no-cost extension) of the grant. We evaluated associations between inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and Creactive protein (CRP) and mammographic density among 542 postmenopausal MAMS participants. IL-6, TNF-alpha, and CRP levels were not independently associated with dense breast area, nondense breast area or percent density in this study population. The results of this analysis were recently accepted for publication in Breast Cancer Research and Treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA542413
Entities
People
- Brenda Diergaarde
- Eleanor Feingold
- Robert Ferrell
Organizations
- University of Pittsburgh