Gene Expression Analysis Of Circulating Hormone Refractory Prostate Cancer Micrometastases

Abstract

This final report for the Physician Research Training Award summarizes work on the genetic analysis of circulating hormone refractory prostate cancer micrometastases. As metastatic tissue is often inaccessible in advanced prostate cancer patients, analysis of circulating tumor cells may provide understanding of the biology of hormone refractory prostate cancer as well as chemotherapy resistance. Oligonucleotide array comparative genomic hybridization allows the assessment of genetic changes that may occur in the process of metastasis and chemotherapy resistance. Genomic profiling using this technology will go beyond cell counting, and circumvent technical complexities related to working with RNA. Using the Vitatex cell isolation system, preliminary data suggested that reproducible genomic alterations are observed in the circulating tumor cells isolated from patients with metastatic hormone refractory prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2011
Accession Number
ADA542509

Entities

People

  • Jonathan E Rosenberg

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemotherapy
  • Gene Expression
  • Health Services
  • Hematologic Diseases
  • Medical Personnel
  • Oncology

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics
  • Systems Analysis and Design

Technology Areas

  • Biotechnology