Targeted Analysis of KLF6/KLF6-SV1 Regulating Pathways in Prostrate Cancer Development and Metastasis
Abstract
KLF6 is a member of the Kruppel-like transcription factor family and it was first identified as a tumor suppressor gene frequently inactivated in Prostate cancer (PCa) (1, 2). A single germline SNP increases PCa risk and KLF6 gene alternative splicing to produce KLF6-SV1, which promotes tumor cell growth and metastasis (3, 4, 5). Since KLF6 was first discovered many downstream, cancer-relevant targets have since been described to be regulated by KLF6 and KLF6-SV1 (1, 6-11). However, less is known about the molecular pathways that regulate the function of these proteins. Therefore, the main purpose of this project is to identify the molecular pathways by which KLF6/KLF6-SV1 are involved in the initiation, progression and metastasis of PCa.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA542531
Entities
People
- Rosa E. Rodriguez-burgos
Organizations
- Icahn School of Medicine at Mount Sinai