Respiratory Challenges in Breast Cancer: Potential for Enhanced Diagnostics and Therapy
Abstract
For the second year of this project, we continued to monitor the changes in endogenous tissue chromophores such as oxy-, deoxy-, total hemoglobin concentration, tissue oxygen saturation, lipid and water contents during tumor growth and chemotherapy using a diffuse optical imaging system. From clinical study, we found that responding tumors show oxyhemoglobin flare within 1 week post neoadjuvant chemotherapy. To confirm this, we monitored the changes of endogenous chromophores post chemotherapy and compared those with controls. We found that functional changes such as oxy-, deoxyhemoglobin, and water precedes the change in tumor volume. This proved our hypothesis that functional changes should occur prior to physical changes when tumors respond to therapy. We have also administered vascular disrupting agents and monitored the changes in tumor oxygenation and blood volume and compared those with contralateral normal breast tissues. We found that vascular disrupting agents work mainly on tumors and also they are more effective in large tumors than small tumors. We also employed Raman spectroscopic measurements on normal tissues near tumor cell inoculation and observed the Raman signal changes as tumor grows.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA542555
Entities
People
- Jae G. Kim
Organizations
- Beckman Laser Institute