Treatment of Traumatic Brain Injury by Localized Application of Subatmospheric Pressure to the Site of Cortical Impact
Abstract
Each major war tends to have a 'signature injury', with traumatic brain injury (TBI) associated with the Iraq war (Operation Iraqi Freedom II and Operation Enduring Freedom) due to the high incidence of personnel injured by IED (improvised explosive devices). The large gyrencephalic brain of swine is similar to humans, thus a swine model of a controlled cortical impact (CCI injury) treated by the controlled application of sub-atmospheric pressure was employed. Work completed in Year 1 showed that application of 100 mm Hg to the site of the CCI resulted in a significantly (p < 0.01) smaller mean contused brain tissue volume (3.44 + 1.14 cu cm) than non-treated injuries (6.59 + 1.76 cu cm) or 50 mm Hg treatment (9.49 + 3.71 cu cm). Similarly, the mean intra-cranial hemorrhagic volume for treated (100 mm Hg) injuries (53.31 + 67.81 cu mm) was significantly smaller (p < 0.01) than that seen in non-treated (375.75 + 348.9 cu mm) or treated (50 mm Hg) injuries (606.84 + 364.05 cu mm). Thus, application of 100 mm Hg sub-atmospheric pressure resulted in significantly smaller areas of injury and hemorrhage following a focal injury in a swine model compared to no treatment or application of lower levels of applied vacuum.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA542618
Entities
People
- Michael Morykwas
Organizations
- Wake Forest University