Oxidative Stress, DNA Repair and Prostate Cancer Risk

Abstract

Oxidative stress, which results from an imbalance between ROS and antioxidant capacities, can cause a wide range of direct or indirect DNA damage. There are extensive DNA repair systems that can correct DNA damage caused by ROS before cell replication and mutation fixation. Although oxidative stress appears to be important in the etiology of prostate cancer, so far there is no study to comprehensively investigate the association between DRC of oxidative DNA damage as a phenotype and prostate cancer risk. We hypothesize that DRC of oxidative DNA damage as a phenotype may modify prostate cancer risk. So far, the study has recruited 287 cases and 276 controls. The proposed molecular analysis has progressed smoothly for all three specific aims.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2010
Accession Number
ADA542698

Entities

People

  • Hua Zhao

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • Antioxidants
  • Biological Sciences
  • Biomedical Research
  • Cancer
  • Department Of Defense
  • Etiology
  • Genomic Instability
  • Information Operations
  • Mutations
  • Neoplasms
  • Ovarian Cancer
  • Oxidative Stress
  • Phenotypes
  • Prostate
  • Prostate Cancer
  • Risk Factors

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology