Breast Density Assessment by Dual Energy X-ray Absorptiometry in Women and Girls
Abstract
Mammographic density has been used as a biomarker for breast cancer risk. In contrast, Dual Energy X-ray Absorptiometry (DXA) has extremely low radiation. The specific aims of this project among adult women and their adolescent daughters were to [1] Correlate breast density measured by DXA with mammographic density among adult women; [2] Compare the association of known breast cancer risk factors with breast density from DXA scans to their association with mammographic density; [3] Assess DXA breast density by Tanner stage of breast maturation among adolescent girls [4] Relate DXA breast density to other observable measures of pubertal maturation; and [5] Examine the relation between breast density measured by DXA in mothers and daughters. We recruited 101 mothers 30 years and older and their daughters aged 10-16 years, representing the multiethnic population of Hawaii. These results indicate that the heritability of breast volume and amount of dense tissue is already visible in adolescence, but an association for percent density may only become apparent at a later time. The current findings suggest the potential use of DXA as a low-radiation option in evaluating longitudinal changes in breast tissue composition in combination with body fat measures and other heritable risk factors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA542911
Entities
People
- Gertraud Maskarinec
Organizations
- University of Hawaiʻi System