Mechanisms in Chronic Multisymptom Illnesses
Abstract
The overall objectives of this cooperative agreement are to conduct research in pursuit of identifying the physiologic mechanisms responsible for the symptoms of pain, fatigue, and memory difficulties commonly seen in patients with Chronic Multisymptom Illnesses (CMI) (i.e., fibromyalgia, chronic fatigue syndrome, Gulf War Illnesses, etc.); to identify the risk factors for developing these syndromes as well as programs aimed at both preventing these illnesses and treating established cases. These objectives will be achieved through multiple research studies using innovative, technologically advanced (e.g., functional MRI and telemedicine) methodologies in a multidisciplinary environment. Various studies will be conducted to explore all aspects of pain processing, the effects of exercise deprivation and sleep reduction on symptomatology, the ability of exercise and/or cognitive behavioral therapies to alter patients' locus of control for pain, the neurobiological mechanism(s) of acupuncture on analgesia, the presence of hypersensitivity to auditory stimuli, and the effectiveness of cognitive behavioral therapy delivered via telemedicine and the internet. These studies will be conducted on well-characterized cohorts of CMI subjects and healthy controls taken from our burgeoning subject registry. Research continues at the University of Michigan, Ann Arbor, MI and Avera Research Institute, Sioux Falls, SD.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2009
- Accession Number
- ADA543568
Entities
People
- Daniel J. Clauw
Organizations
- University of Michigan