Multidisciplinary Analysis of Cyclophilin A Function in Human Breast Cancer

Abstract

The goal of this project was to understand how cyclophilin A (CypA) regulates the prolactin receptor (PRLr) signaling. The data have demonstrated that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase (PPI) activity, binds to and regulates the function of the PRLr. Furthermore, point mutagenesis analysis has implied that a single prolyl imide bond (Pro-334) within the X-Box motif of intracellular domain of the PRLr is most likely responsible for the observed effects of CypA on the PRLr signaling. Finally, we have conducted several proof-of-concept studies that may lead to novel anti-breast cancer agents.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2011
Accession Number
ADA543741

Entities

People

  • Jiamao Zheng

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Department Of Defense
  • Epithelial Cells
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Surface Plasmon Resonance

Readers

  • Human-Computer Interaction (HCI).
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).