Sympathetic Nerves in Breast Cancer: Angiogenesis and Antiangiogenic Therapy

Abstract

We have demonstrated sympathetic tyrosine hydroxylase-positive (TH+) nerve fibers innervating breast tumors growing in the murine mammary fat pad. To study the role of the sympathetic nervous system in breast tumor progression, we used two approaches: 1) 6-hydroxydopamine (6-OHDA) to destroy sympathetic nerves and 2) desipramine to increase tumor NE concentration. 6-OHDA treatment reduced 4T1 tumor NE concentration by 60%, demonstrating that tumor NE is derived primarily from sympathetic nerve fibers. With sympathetic denervation, tumor weight and IL-6 concentration were reduced. Chronic desipramine treatment increased tumor NE, but it elicited only a small, transient increase in tumor growth. The relatively small magnitude of the treatment effects suggest that homeostatic mechanisms compensate for altered NE availability.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2011
Accession Number
ADA543744

Entities

People

  • Kelley Madden

Organizations

  • University of Rochester

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Angiogenesis
  • Antidepressants
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cell Line
  • Cells
  • Endocrine Glands
  • Endothelial Cells
  • Medical Personnel
  • Neoplasms
  • Nerve Fibers
  • Nerves
  • Nervous System
  • Statistical Analysis
  • Sympathetic Nervous System

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Oncology (Cancer Research).