Characterizing the Relationship Between Blast Exposure and Mild TBI with Dynamic Modeling and Testing in a New Mouse Model
Abstract
The purpose of this research is to determine through analytical modeling and animal-based experiments the blast-level threshold for mild traumatic brain injury in humans. We have cataloged brain material properties and determined axon bundle geometry. Basic axon geometry has been determined for a finite element (FE) model and modified geometry has also been developed. Blast pressure profiles for small IED and other blast scenarios have been determined from literature reviews. Preliminary models have been constructed. In a tandem effort, laboratory-based animal experiments are being conducted to determine the impact forces that induce single or repetitive mTBI in mice. A 0.196J impact to the closed mouse skull caused a transient loss of consciousness, which suggests that a mild TBI occurred. Two or three impacts with a 24 hour inter-injury periodicity caused a reduced latency to find the hidden platform on the Morris water maze, which suggests a learning or acquisition deficit. We also observed increased anxiety as compared to uninjured mice in animals that received 3 mTBIs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 2010
- Accession Number
- ADA544194
Entities
People
- Candace L. Floyd
- W. S. Shepard Jr.
Organizations
- University of Alabama