Genetic and Environmental Pathways in Type 1 Diabetes Complications
Abstract
Type 1 Diabetes (T1D) is associated with increased risk of T1D-Nephropathy (T1DN) and is usually accompanied by other diabetic-related complications such as retinopathy, neuropathy, blood pressure elevation, and high risk of cardiovascular morbidity and mortality. Sixteen million people in the US have diabetes with 800,000 new cases diagnosed each year. Diabetic complications affect most diabetic patients. Diabetes occurs in men, women, children and the elderly. African, Hispanic, Native and Asian Americans are particularly susceptible to its most severe complications. An estimated 20% to 40% of T1D patients will develop diabetic nephropathy, clinically first evidenced by microalbuminuria, during their lifetime. If untreated nearly all T1D patients experiencing microalbuminuria will progress to overt nephropathy, evidenced by macroalbuminuria, and culminating in T1D-End Stage Renal Disease (T1D-ESRD). Improved prediction of risk for developing diabetes and diabetic complications among active duty members of the military, their families and retired military personnel will potentially allow focused preventative treatment of at-risk individuals, providing significant healthcare savings and improved patient well being.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA544296
Entities
People
- Massimo Trucco