Novel Inhibitors of Protein-Protein Interaction for Prostate Cancer Therapy
Abstract
The goal of this research is to firmly establish the mechanism of androgen receptor (AR)- JunD heterodimer induction of the SSAT gene leading to oxidative stress that contributes to the development and progression of prostate cancer (PCa), and to identify small molecules that specifically inhibit this AR-JunD interaction and prevent development/progression of PCa in pre-clinical models. Data from this research will identify the most efficacious drug to be further developed for preclinical toxicity testing and clinical trials for PCa that fall beyond the scope of this proposal. Significant findings during Year 1 of the research include: identification of sequences in the SSAT promoter that are relatively more important in the androgen activated AR-JunD induction of SSAT; identification of 13 small molecules that specifically inhibit AR-JunD; and classification of 12 of the 13 small molecules as non-antiandrogens to be further tested for efficacy against PCa models as proposed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2011
- Accession Number
- ADA544659
Entities
People
- George Wilding
Organizations
- University of Wisconsin–Madison