The Coagulopathy of Trauma: A Review of Mechanisms
Abstract
For the U.S. Military, war-related traumatic injury deaths exceeded 5,000 in the last decade, and many more soldiers and marines have been seriously injured by improvised explosive devices, high-velocity munitions, and vehicular events. These events have brought the problem of the acute coagulopathy of trauma to the fore. The goal of this project was to increase basic knowledge about the coagulopathy specifically associated with severe trauma. Our objectives were to assemble a precise and detailed database on coagulation factor levels over the course of resuscitation of severely injured, hemorrhaging, patients. Our proposed research was to be conducted with a 24 hour delay of informed consent, which was approved by our IRB. The Air Force ultimately denied approval for a delayed consent. The results are thus limited. Nevertheless, we enrolled 15 patients including several who were shot, others who were severely injured in other ways and four who ultimately died. Despite the small number of patients recruited, the demographics and methods of injury were typical of modern American civilian urban Level I trauma center populations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA544814
Entities
People
- Bertil Bouillon
- Carl J. Hauser
- David B. Hoyt
- John B Holcomb
- John R Hess
- Karim Brohi
- Kevin Mackway-jones
- Michael J. Parr
- Richard P. Dutton
- Sandro B. Rizoli
- Tetsuo Yukioka
- Yoram Kluger
Organizations
- University of Maryland, Baltimore