Hypoxic Hypoxia at Moderate Altitudes: State of the Science
Abstract
A systematic literature review of research on acute hypoxic hypoxia within the range of 8,000 to 15,000 feet pressure altitude was conducted. The goal was to evaluate the state of the science regarding mild hypoxic impairment of mental functions, sensory deficits, and other pertinent findings that may affect aviation-related duties. Defence Technical Information Center and Dialog searchers were performed in conjunction with a research librarian. The minimum altitude where hypoxic deficits manifest remains unclear. Cognitive testing is often not reproducible under similar research conditions; measurements of visual decrements produce more consistent results. Cognitive deficits seem to be particularly difficult to quantify, possibly due to individual variability and lack of sensitivity and/or specificity of the cognitive test utilized. The manifestation of acute mild hypoxia at moderate altitude may not be solely a function of partial pressure of oxygen, but rather the balance of respiratory gases, possible disruption of oxygen-dependent neurotransmitter synthetic pathways, and the inherent hypoxia sensitivity of various neuron populations.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2011
- Accession Number
- ADA545310
Entities
People
- Frank Petrassi
- John Ramiccio
- Patricia L. Walters
- Steve Gaydos
Organizations
- United States Army Aeromedical Research Lab