Roles of SGK Isoform Signaling in Breast Cancer Migration and Invasion

Abstract

14. ABSTRACT My experiments indicate that Serum and Glucocorticoid regulated Kinase (SGK) proteins facilitate breast cancer invasive migration, a critical step for ultimate cancer metastasis to other organs. The activation of SGK during cellular stress conditions, such as low oxygen found within a tumor, makes this data increasingly imperative for therapeutics. The research shown here demonstrates SGK loss in highly mestatic breast cancer cell lines causes an invasive migration defect. Conversely, the overexpression of SGK isoforms in breast cancer cell lines causes an enhancement of invasive migration. These discoveries are helping to elucidate new mechanisms that can be targeted for more specific and successful therapies to block breast cancer metastasis. Known targets of SGK proteins are being examined for their contribution to the metastatic properties of breast cancer cells. These studies will determine the importance of SGK proteins as putative therapeutic targets for breast cancer motility.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2011
Accession Number
ADA545698

Entities

People

  • Jessica Gasser

Organizations

  • Harvard College

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Hot Spots
  • Infection
  • Information Operations
  • Kinases
  • Migration
  • Mutations
  • Neoplasms
  • Transfection
  • Wound Infections

Fields of Study

  • Biology
  • Chemistry

Readers

  • Oncology (Cancer Research).